Polyester-based excipients to formulate lipophilic drugs into nanoparticles and a method for producing said nanoparticles

Data di pubblicazione

27-03-2018

Codice

CH.17.015.A

Stato

Non attivo

Data di priorità

04-10-2017

Titolare

Politecnico di Milano

Dipartimento

Department of Chemistry Materials and Chemical Engineering

Autori

Davide Moscatelli, Umberto Capasso Palmiero, Massimo Morbidelli (PoliMi), Maurizio D'Incalci (Istituto Mario Negri)

Descrizione

The invention consists in a new class of materials biocompatible and biodegradable for the transport of oligonucleotides based on PCLs (PolyCraptoLactones) diacrylates, and their synthesis method. These materials can transports oligonucleotides by the adoption of a living polymerization (a ring opening polymerization) and the Michael addition polymerization that permits to obtain poly-b-amino esters, that are more biocompatible than the PBAEs produced by bisphenol A dicarylate.

Campo di applicazione

Since the invention is a carrier of exogenous oligonucleotides, in other words a drug deliver, the main application is related to the pharmaceutics word for cancer immunotherapy, apoptosis-associated diseases, vaccines and genomic engineering, amongst others.

Vantaggi

The main advantage of the poly-b-amino esters as mRNA carriers is related to the simplicity of synthesis, transfection efficiency and degradability. But differently from the PBAEs that derives from bisphenol A diacrylate (high transfer efficient mRNA transporter), that degrades into butanediol (a psychoactive drug) and into bisphenol A (potentially toxic) that are considered as dangerous compounds, our new class of diacrylates is more safe and biocompatible.

Contatto

licensing.tto@polimi.it